There exists one or more webservice bugs in ColdFusion 10 that will leak all your memory over a very short amount of time. We build a SOAP based webservice with ColdFusion 8 + 10 that is not running stable at all for around 2 years now. First the issues we have seen in CF8 have been caused by the very outdated Axis 1.x version used under the hood, but later in CF10 they used Axis 2 and the issues should have been resolved, but SOAP is still a mess under ColdFusion and very very unstable! We are in month 9 with analysis and gave up with useless Adobe Support.
We moved our webservice to JSON format. The memory leak disapeared with JSON and the webservice runs smooth for many weeks now. One day before we switched I received a hotfix from Adobe that will fix at least a bug in the webservice that caused multiple initialisations of a webservice. Something that should never happen. It can be compared to an OnApplicationStart that should be executed only once and block all other request until completed, but CF10 runs several webservice initialisations in parallel what is not correct. Adobe has a non-public patch for this available now.