There exists one or more webservice bugs in ColdFusion 10 that will leak all your memory over a very short amount of time. We build a SOAP based webservice with ColdFusion 8 + 10 that is not running stable at all for around 2 years now. First the issues we have seen in CF8 have been caused by the very outdated Axis 1.x version used under the hood, but later in CF10 they used Axis 2 and the issues should have been resolved, but SOAP is still a mess under ColdFusion and very very unstable! We are in month 9 with CF10 analysis and gave up with useless Adobe Support.
The coldfusion application running here has been encapsulated on one CF instance and has a CFML code size of ~3MB. It leaked up to 4GB of trusted cache memory over 1-2 days. The requests made to our webservice have been made by one PHP application only.