There exists one or more webservice bugs in ColdFusion 10 that will leak all your memory over a very short amount of time. We build a SOAP based webservice with ColdFusion 8 + 10 that is not running stable at all for around 2 years now. First the issues we have seen in CF8 have been caused by the very outdated Axis 1.x version used under the hood, but later in CF10 Axis 2 was integrated and the issues should have been resolved by upgrading the Applications to this version. But SOAP is still a mess under ColdFusion 10 and very very unstable! We are in month 9 with CF10 analysis and gave up with useless Adobe Support.
We migrated our webservice to JSON output format now. Nothing else in the logic has been changed, only the output. The memory leak disappeared with JSON and the webservice runs smooth for several weeks now. Nothing has been changed on server configuration.